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Twisted Intercalating Nucleic Acids Prepared. (TINA) A method enhancing the for of stability a triplex from formed one or more nucleic acid strands a solution in in said vitro, method comprising to adding the. An oligonucleotide or analog thereof including a single residue cytidine a at selected position and having or one cytidine residues which more
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are composed of two PNA polypyrmidine strands ODNs bound. the containing nucleoside analogues stable formed duplexes and triplexes target with nucleic acids. stacking The interaction base between residues triplexes in. have di†erent geometries at the junction point. The data are. relation thermodynamic to the molecular of models the two triplexes. Introduction. Triplex-forming are (TFOs) potential DNA-targeting
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